|
KMID : 0616120120430020184
|
|
Korean Journal of Pharmacognosy
2012 Volume.43 No. 2 p.184 ~ p.191
|
|
|
Screening of Herbal Medicines for Phosphodiesterase 5 Inhibitor
|
|
Lee Keyong-Ho
Kim Byung-Soo
Rhee Ki-Hyeong
|
|
|
Abstract
|
|
|
|
The aim of this study was to explore the potent phosphodiesterase type 5 (PDE %) inhibitor from various herbal medicines for erectile dysfunctions. In this study, 61 herbal medicines, which were extracted with ethanol, have been investigated with PDE 5 assay using enzyme inhibitory activity on 22 species of herbal medicines. Of these, 5 species of herbal medicines, Cnidium monieri, Cuscuta chinensis, Epimedium koreanum, Morinda officinalis, and Tribulus terrestris were exhibited stronger inhibitory effect against phosphodiesterase 5 (PDE 5) among 61 species; Cnidium monieri (IC50 = 33.7 μg/ml), Cuscuta chinensis (IC50 = 65.7 μg/ml), Epimedium koreanum (IC50 = 90.3 μg/ml), Morinda officinalis (IC50 = 48.7 μg/ml) and Tribulus terrestris (IC50 = 32.5 μg/ml).
|
|
|
KEYWORD
|
|
|
Phosphodiesterase 5, Erectile dysfunctions, Herbal medicine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|